Hyperlipidemic arterial dysfunction.

Hyperlipidemic arterial dysfunction.

About 10 years ago, Furchgott and Zawadzki2 /... made a remarkable observation that helped .Lk.clarify variable effects of acetylcholine on arterial tone. They demonstrated that isolated arteries relaxed in response to acetylcholine and other endogenous vasoactive agents only in the presence of an intact endothelium and postulated that endothelial cells released a diffusible vasodilator princip...

Arterial Stiffness and Endothelial Dysfunction

Erectile dysfunction in arterial hypertension

Funding / potential competing interests: No financial support and no other potential conflict of interest relevant to this article were reported. Correspondence: Thomas Dieterle; MD Divisional Medical and Scientific Affairs, Roche Diagnostics, Basel, and Department of Internal Medicine, University Hospital Basel Grenzacherstrasse CH – 4070 Basel thomas.dieterle[at]usb.ch; thomas.dieterle[at]roc...

Endothelial dysfunction and peripheral arterial disease.

We read with interest the study of Loffredo et al. investigating the association of oxi-dative stress and endothelial function in patients with peripheral arterial disease (PAD). The authors demonstrated that flow-mediated vasodilation (FMD) of the brachial artery was significantly lower in patients with PAD compared with controls, whereas 8-hydroxy-2-deoxy-2-deoxyguanosine (a marker of oxidati...

Endothelial dysfunction, arterial stiffness, and heart failure.

Outcomes for heart failure (HF) patients remain suboptimal. No known therapy improves mortality in acute HF and HF with preserved ejection fraction; the most recent HF trial results have been negative or neutral. Improvement in surrogate markers has not necessarily translated into better outcomes. To translate breakthroughs with potential therapies into clinical benefit, a better understanding ...